How can I improve IVF results?

Date: 17.11.2015

What methods helps to improve IVF results?
  • Cult-Active. It is an innovative method that is used in order to activate egg after fertilization. A small amount of fertilized cells indicates that eggs are immature. Protein contained in sperm starts the activation of the egg. Upon cultivation of the egg occurs a rapid increase in intracellular calcium concentration.
  • EmbryoGen. Until recently it was possible to control and ensure optimal conditions from the moment of egg collection until embryo transfer. Now with the new environment EmbryoGen it is possible to improve the development of the embryo also in the female’s uterus. The embryos are cultured in this environment until the third day. According to the latest research it improves communication between mother and fetus at the cellular level. This is necessary because one of the causes of miscarriage is the woman body's immune response on an embryo as a foreign body. For women after 35 years there is an increased risk of miscarriage, so for these patients is recommended to use EmbryoGen.
  • EmbryoGlue. Specially developed environment is used during embryo transfer, it improves the implantation of embryos. This environment contains hyaluronic acid, carbohydrates and amino acids, which interact as a binding substance at the time of embryo implantation in the uterus. The scientific researches point out that at the time of implantation of the embryo in the uterus contains an elevated level of hyaluronic acid, which helps for the embryo’s better implantation. The increased level of hyaluronic acid in EmbryoGlue, in which the embryo is placed before the embryo transfer, improves its ability to attach in the uterus of women.
  • EmbryoScope. This is the latest technology that improved results of infertility treatment by 20%. EmbryoScope is an incubator that controls not only the temperature and carbon dioxide, but also oxygen required embryos in small quantities. There is a video camera in incubator EmbryoScope that records all the stages of embryo development, and the environment in the incubator is as close as possible to the conditions in the mother's tummy. To determine how the embryo develops, it is enough to look at the screen, it is not necessary to remove the embryos from the incubator each time, preventing the process of their cultivation. An expert with the help of a special computer program can at any time follow the process of dividing an embryo, detect errors - too slow or rapid division. Therefore, on the fifth day, you can see which one from the embryos has better chance to implant during embryo transfer and continue to develop.
  • ERA test. ERA test (Endometrial Receptivity Array) is the genetic tests to determine the receptive properties of the endometrium - the readiness of endometrium to the adoption and implantation of the embryo in a specific period. ERA test helps each woman to determine individually the best time for the implantation of the embryo. This test is performed for patients after a failed implantation of good quality embryos (at least three embryo transfer with negative results in women younger than 37 years old or two - in women after 37 years). It is recommended for women with an anatomically unchanged uterus and normal endometrial thickness (≤6 mm) with no visible abnormalities. ERA test allows to determine the shift of "implantation’s window".
  • PICSI. Detailed Sperm Selection Technique. During the ICSI procedure (the injection of a single spermatozoon into the cytoplasm of egg) select a spermatozoon with the best morphology and motility, which is injected into an egg. Before beginning to use the method of PICSI, visual assessment of sperm was the only way to choose the best spermatozoon to fertilize an egg. However, the spermatozoa with good mobility and morphology may have other defects that cannot be visually identified, for example, DNA fragmentation, delayed development. These defects affect the quality and development of embryos that subsequently can cause an abortion. Using PICSI method, it is possible to inject physiologically better spermatozoon into the cytoplasm of an egg. This method enhances the selection of sperm up to 98%. In this technique, the sperm is placed into a hyaluronic acid, which attracts mature spermatozoa. Only fully mature sperm cells, which have reached the final stage of spermatogenesis, developed hyaluronic acid receptors. There are increased fragmentation of DNA, aneuploidy (changes in the number of chromosomes) and immature cytoplasm in immature sperm. The new method PICSI increases the chances of a successful pregnancy.
  • Array Comparative Genomic Hybridization (aCGH) on microchips. This unique technique allows simultaneous testing of all chromosomes in an embryo before the embryo transfer and provides high accuracy for the chromosomal abnormalities identification before the embryo transfer and implantation. Within the IVF cycle, there is available now unique research of the embryos before they are transferred into the uterus - PGS (Preimplantation Genetic Screening) and PGD (Preimplantation Genetic Diagnosis). Embryonic Preimplantation Genetic Testing (PGS and PGD) make it possible to choose the best and most viable genetically competent embryos, effectively increase the chance of implantation, clinical pregnancy and success already after the first cycle of PGS/ PGD.
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